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Ranitidine Hydrochloride n/v/d/c no antacids w/i 1 hr 12
acute porphyria
reduces absorption of antifungals
Antacids reduce absorption
Omeprazole n/v/d
Bone loss
a breakfast 18
Lactation
Reduces absorption of antifungals
Increases risk of warfarin, phenytoin
and diazepam toxicity (warphendie)
ginko and st. johns wort decrease levels
Sucralfate n/v/c
dyspepsia
4x day a meals not for children No antacids within 30-60 minutes
No admin within 2 hours of
warphendie
fluoroquinolone antibiotics
digoxin
tetracycline
theophylline
Misoprostol n/d
dyspepsia
abdominal pain
Dysmennorhea, uterine cramping,
and spotting
4x day c meals Category x Antacids which contain Mg
worsen d
Ondansetron d
headache
dizziness
chemo: 30 min-4/8
rad: 1/2 hr-8 prn
anes: 1 hr
4 Rifampin
decreases ondansetron levels
Diphenoxylate/atropine
*naloxone
c
sedation/dizziness
anticholinergic effects
4x day in 5 mg doses 2
IBD
Glaucoma
pseudomem. enterocolitis
GI bleeding
Ileus
MAOIs increase
risk of adverse effects

Alosetron severe c
ischemic colitis
2x day po
re-eval p 4wks
severe c
divurticulitis
crohns disease
Ischemic or ulcerative colitis
GI per. stricture or obstruction
thrombophlebitis
toxic megacolon
Fluvoxamine increases levels
Cytochrome P450 inducers
like phenobarbitol
decrease levels
Lubiprostone n/v/d+farts
headache
2x day c food severe d
diverticulitis
crohns disease
Ulcerative colitis
GI obstruction
volulus

Sulfasalazine

!orangey skin and urine

n/v/d
fever
rash
athralgia
hematologic disorders
(agranulocytosis,
hemolytic and macrocytic
anemias)
p meals folic acid deficiency
porphyria
GI/urinary obstruction
agranulocytosis
Megaloblastic anemia

Fe & Antibiotics
effect absoption
decreases absorption of
digoxin
Azathioprine n/v/anorexia
hepatitis
bone marrow suppression
(-penias + agranulocytosis)
pancreatitis
anuria
Active infections
live virus vaccines
Allopurinol increases
drug levels